James P. Warne, PhD
James P. Warne is an associate specialist in the UCSF Diabetes Center. He received a BSc(hons) in biology from Imperial College of Science, Technology and Medicine (University of London), UK, and a PhD in pharmacology at Imperial College Faculty of Medicine. His research into the role of stress hormones (glucocorticoids) in energy balance and obesity that originated during his graduate studies was continued in the Department of Physiology at UCSF, where he worked with Mary Dallman.
His research uses integrative physiological approaches to study the reciprocal interactions between brain and body in the regulation of metabolism and in the development of metabolic diseases, such as obesity, diabetes, and hepatic steatosis. His work explores two interrelated streams:
1. The interplay between, and sites of action of, glucocorticoids and insulin in the regulation of energy balance, glucose homeostasis and the stress response and the effects of disrupting the ratio of these two hormones in the development of obesity and insulin resistance.
2. The role of signaling in specific neuronal populations within the hypothalamus in the regulation of peripheral lipid metabolism, glucose homeostasis and energy balance, with special emphasis on the metabolic responses to different dietary conditions and stress.
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