Ida Sim, PhD, MD

PROF IN RES-HCOMP
Medicine

Ida Sim, MD, PhD is a primary care physician, informatics researcher, and entrepreneur. She is a Professor of Medicine at the University of California, San Francisco, where she co-directs Informatics and Research Innovation at UCSF's Clinical and Translational Sciences Institute, and is Director of Digital Health for the Division of General Internal Medicine. Dr. Sim is a global leader in the technology and policy of large-scale health data sharing.

She is a co-founder of Open mHealth, a non-profit organization that is breaking down barriers to mobile health app and data integration through an open software architecture. Open mHealth is an official working group of the IEEE Standards Association and soon to be a global IEEE standard. Dr. Sim has multiple grants from NIH, NSF, and AHRQ on mobile health methodology and digital health for primary care. In 2019, she co-developed CommonHealth, an open source software suite bringing to the Android ecosystem the equivalent of Apple Health's ability to access and share EHR data.

Dr. Sim is also co-founder of Vivli, the world's largest data sharing platform for participant-level clinical trial data. In 2005, she was the founding Project Coordinator of the World Health Organization's International Clinical Trials Registry Platform, where she led the establishment of the first global policy on clinical trial registration.

Dr. Sim has served on multiple advisory committees on health information infrastructure for clinical care and research, including committees of the National Research Council and National Academy of Medicine. She is a recipient of the United States Presidential Early Career Award for Scientists and Engineers (PECASE), a Fellow of the American College of Medical Informatics, and a member of the American Society for Clinical Investigation.

Publications: 

Time for NIH to lead on data sharing.

Science (New York, N.Y.)

Sim I, Stebbins M, Bierer BE, Butte AJ, Drazen J, Dzau V, Hernandez AF, Krumholz HM, Lo B, Munos B, Perakslis E, Rockhold F, Ross JS, Terry SF, Yamamoto KR, Zarin DA, Li R

Mobile Devices and Health.

The New England journal of medicine

Sim I

How Clinical Trial Data Sharing Platforms Can Advance the Study of Biomarkers.

The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

Li R, Sim I

Effect of Mobile Device-Assisted N-of-1 Trial Participation on Analgesic Prescribing for Chronic Pain: Randomized Controlled Trial.

Journal of general internal medicine

Odineal DD, Marois MT, Ward D, Schmid CH, Cabrera R, Sim I, Wang Y, Wilsey B, Duan N, Henry SG, Kravitz RL

Why we need a small data paradigm.

BMC medicine

Hekler EB, Klasnja P, Chevance G, Golaszewski NM, Lewis D, Sim I

A randomized trial provided new evidence on the accuracy and efficiency of traditional vs electronically annotated abstraction approaches in systematic reviews.

Journal of clinical epidemiology

Li T, Saldanha IJ, Jap J, Smith BT, Canner J, Hutfless SM, Branch V, Carini S, Chan W, de Bruijn B, Wallace BC, Walsh SA, Whamond EJ, Murad MH, Sim I, Berlin JA, Lau J, Dickersin K, Schmid CH

Role of Health Information Technology in Addressing Health Disparities: Patient, Clinician, and System Perspectives.

Medical care

Zhang X, Hailu B, Tabor DC, Gold R, Sayre MH, Sim I, Jean-Francois B, Casnoff CA, Cullen T, Thomas VA, Artiles L, Williams K, Le PT, Aklin CF, James R

A Case for n-of-1 Trials-Reply.

JAMA internal medicine

Kravitz RL, Sim I, Duan N

Finding Benefit in n-of-1 Trials-Reply.

JAMA internal medicine

Kravitz RL, Schmid CH, Sim I

The Global academic research organization network: Data sharing to cure diseases and enable learning health systems.

Learning health systems

Fukushima M, Austin C, Sato N, Maruyama T, Navarro E, Rocca M, Demotes J, Haendel M, Volchenboum SL, Cowperthwaite M, Silverstein JC, Webb C, Sim I, Chase M, Speakman J, Augustine E, Ford DE, Kush R

Patient Perceptions of Their Own Data in mHealth Technology-Enabled N-of-1 Trials for Chronic Pain: Qualitative Study.

JMIR mHealth and uHealth

Whitney RL, Ward DH, Marois MT, Schmid CH, Sim I, Kravitz RL

Effect of Mobile Device-Supported Single-Patient Multi-crossover Trials on Treatment of Chronic Musculoskeletal Pain: A Randomized Clinical Trial.

JAMA internal medicine

Kravitz RL, Schmid CH, Marois M, Wilsey B, Ward D, Hays RD, Duan N, Wang Y, MacDonald S, Jerant A, Servadio JL, Haddad D, Sim I

Center of Excellence for Mobile Sensor Data-to-Knowledge (MD2K).

IEEE pervasive computing

Kumar S, Abowd G, Abraham WT, al'Absi M, Chau DHP, Ertin E, Estrin D, Ganesan D, Hnat T, Hossain SM, Ives Z, Kerr J, Marlin BM, Murphy S, Rehg JM, Nahum-Shani I, Shetty V, Sim I, Spring B, Srivastava M, Wetter D

Evaluating Data Abstraction Assistant, a novel software application for data abstraction during systematic reviews: protocol for a randomized controlled trial.

Systematic reviews

Saldanha IJ, Schmid CH, Lau J, Dickersin K, Berlin JA, Jap J, Smith BT, Carini S, Chan W, De Bruijn B, Wallace BC, Hutfless SM, Sim I, Murad MH, Walsh SA, Whamond EJ, Li T

A Global, Neutral Platform for Sharing Trial Data.

The New England journal of medicine

Bierer BE, Li R, Barnes M, Sim I

Multivariate analysis of the population representativeness of related clinical studies.

Journal of biomedical informatics

He Z, Ryan P, Hoxha J, Wang S, Carini S, Sim I, Weng C

Informatics: Make sense of health data.

Nature

Elliott JH, Grimshaw J, Altman R, Bero L, Goodman SN, Henry D, Macleod M, Tovey D, Tugwell P, White H, Sim I

Center of excellence for mobile sensor data-to-knowledge (MD2K).

Journal of the American Medical Informatics Association : JAMIA

Kumar S, Abowd GD, Abraham WT, al'Absi M, Beck JG, Chau DH, Condie T, Conroy DE, Ertin E, Estrin D, Ganesan D, Lam C, Marlin B, Marsh CB, Murphy SA, Nahum-Shani I, Patrick K, Rehg JM, Sharmin M, Shetty V, Sim I, Spring B, Srivastava M, Wetter DW

The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial.

Trials

Barr C, Marois M, Sim I, Schmid CH, Wilsey B, Ward D, Duan N, Hays RD, Selsky J, Servadio J, Schwartz M, Dsouza C, Dhammi N, Holt Z, Baquero V, MacDonald S, Jerant A, Sprinkle R, Kravitz RL

Visual aggregate analysis of eligibility features of clinical trials.

Journal of biomedical informatics

He Z, Carini S, Sim I, Weng C

Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms.

Studies in health technology and informatics

Ross J, Neylan T, Weiner M, Chao L, Samuelson K, Sim I

A method for analyzing commonalities in clinical trial target populations.

AMIA ... Annual Symposium proceedings. AMIA Symposium

He Z, Carini S, Hao T, Sim I, Weng C

Patient-centered care, collaboration, communication, and coordination: a report from AMIA's 2013 Policy Meeting.

Journal of the American Medical Informatics Association : JAMIA

Brennan PF, Valdez R, Alexander G, Arora S, Bernstam EV, Edmunds M, Kirienko N, Martin RD, Sim I, Skiba D, Rosenbloom T

Academic Medical Centers as digital health catalysts.

Healthcare (Amsterdam, Netherlands)

DePasse JW, Chen CE, Sawyer A, Jethwani K, Sim I

The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research.

Journal of biomedical informatics

Sim I, Tu SW, Carini S, Lehmann HP, Pollock BH, Peleg M, Wittkowski KM

Sponsorship and design characteristics of trials registered in ClinicalTrials.gov.

Contemporary clinical trials

Roumiantseva D, Carini S, Sim I, Wagner TH

Deriving an abstraction network to support quality assurance in OCRe.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Ochs C, Agrawal A, Perl Y, Halper M, Tu SW, Carini S, Sim I, Noy N, Musen M, Geller J

Ontology-based federated data access to human studies information.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Sim I, Carini S, Tu SW, Detwiler LT, Brinkley J, Mollah SA, Burke K, Lehmann HP, Chakraborty S, Wittkowski KM, Pollock BH, Johnson TM, Huser V

Making sense of mobile health data: an open architecture to improve individual- and population-level health.

Journal of medical Internet research

Chen C, Haddad D, Selsky J, Hoffman JE, Kravitz RL, Estrin DE, Sim I

EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Boland MR, Tu SW, Carini S, Sim I, Weng C

Network analysis of clinical trials on depression: implications for comparative effectiveness research.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Bhavnani SK, Carini S, Ross J, Sim I

ExaCT: automatic extraction of clinical trial characteristics from journal publications.

BMC medical informatics and decision making

Kiritchenko S, de Bruijn B, Carini S, Martin J, Sim I

A practical method for transforming free-text eligibility criteria into computable criteria.

Journal of biomedical informatics

Tu SW, Peleg M, Carini S, Bobak M, Ross J, Rubin D, Sim I

Analysis of eligibility criteria complexity in clinical trials.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Ross J, Tu S, Carini S, Sim I

Ontology mapping and data discovery for the translational investigator.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Wynden R, Weiner MG, Sim I, Gabriel D, Casale M, Carini S, Hastings S, Ervin D, Tu S, Gennari JH, Anderson N, Mobed K, Lakshminarayanan P, Massary M, Cucina RJ

The human studies database project: federating human studies design data using the ontology of clinical research.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Sim I, Carini S, Tu S, Wynden R, Pollock BH, Mollah SA, Gabriel D, Hagler HK, Scheuermann RH, Lehmann HP, Wittkowski KM, Nahm M, Bakken S

Formal representation of eligibility criteria: a literature review.

Journal of biomedical informatics

Weng C, Tu SW, Sim I, Richesson R

Development and evaluation of a study design typology for human research.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Carini S, Pollock BH, Lehmann HP, Bakken S, Barbour EM, Gabriel D, Hagler HK, Harper CR, Mollah SA, Nahm M, Nguyen HH, Scheuermann RH, Sim I

Compliance of clinical trial registries with the World Health Organization minimum data set: a survey.

Trials

Moja LP, Moschetti I, Nurbhai M, Compagnoni A, Liberati A, Grimshaw JM, Chan AW, Dickersin K, Krleza-Jeric K, Moher D, Sim I, Volmink J

Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs.

Academic medicine : journal of the Association of American Medical Colleges

Bernstam EV, Hersh WR, Johnson SB, Chute CG, Nguyen H, Sim I, Nahm M, Weiner MG, Miller P, DiLaura RP, Overcash M, Lehmann HP, Eichmann D, Athey BD, Scheuermann RH, Anderson N, Starren J, Harris PA, Smith JW, Barbour E, Silverstein JC, Krusch DA, Nagarajan R, Becich MJ

Unintended consequences of health information technology: a need for biomedical informatics.

Journal of biomedical informatics

Bernstam EV, Hersh WR, Sim I, Eichmann D, Silverstein JC, Smith JW, Becich MJ

Keeping raw data in context.

Science (New York, N.Y.)

Sim I, Chute CG, Lehmann H, Nagarajan R, Nahm M, Scheuermann RH

Changes to NIH grant system may backfire.

Science (New York, N.Y.)

Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE

An interactive tool for visualizing design heterogeneity in clinical trials.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Hernandez ME, Carini S, Storey MA, Sim I

Automated information extraction of key trial design elements from clinical trial publications.

AMIA ... Annual Symposium proceedings. AMIA Symposium

de Bruijn B, Carini S, Kiritchenko S, Martin J, Sim I

Characterizing primary care research: PCROM versus BRIDG.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Speedie SM, Taweel A, Sim I, Arvanitis TN, Arvanitis T, Delaney B, Peterson KA

The Primary Care Research Object Model (PCROM): a computable information model for practice-based primary care research.

Journal of the American Medical Informatics Association : JAMIA

Speedie SM, Taweel A, Sim I, Arvanitis TN, Delaney B, Peterson KA

Reporting the findings of clinical trials: a discussion paper.

Bulletin of the World Health Organization

Ghersi D, Clarke M, Berlin J, Gülmezoglu A, Kush R, Lumbiganon P, Moher D, Rockhold F, Sim I, Wager E

[Principles of the international registry of protocols and clinical trial results based on health interventions in human beings: Ottawa Declaration (part 1)].

Revista panamericana de salud publica = Pan American journal of public health

Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C

Clinical trial registration: transparency is the watchword.

Lancet (London, England)

Sim I, Chan AW, Gülmezoglu AM, Evans T, Pang T

Assessing clinical trial results.

Science (New York, N.Y.)

Chan AW, Sim I, Gülmezoglu AM, Unterlerchner P, Karam G, Pang T

International clinical trial registration: any progress?

Wiener klinische Wochenschrift

Gülmezoglu AM, Sim I

A taxonomic description of computer-based clinical decision support systems.

Journal of biomedical informatics

Berlin A, Sorani M, Sim I

National Center for Biomedical Ontology: advancing biomedicine through structured organization of scientific knowledge.

Omics : a journal of integrative biology

Rubin DL, Lewis SE, Mungall CJ, Misra S, Westerfield M, Ashburner M, Sim I, Chute CG, Solbrig H, Storey MA, Smith B, Day-Richter J, Noy NF, Musen MA

RuleEd, a web-based semantic network interface for constructing and revising computable eligibility rules.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Olasov B, Sim I

The value of electronic health records in solo or small group practices.

Health affairs (Project Hope)

Miller RH, West C, Brown TM, Sim I, Ganchoff C

Quantifying the gap between proof and practice.

Evidence-based cardiovascular medicine

Sim I, Cummings SR

Physicians' use of electronic medical records: barriers and solutions.

Health affairs (Project Hope)

Miller RH, Sim I

Characteristics of outpatient clinical decision support systems: a taxonomic description.

Studies in health technology and informatics

Berlin A, Sorani M, Sim I

Electronic medical records in solo/small groups: a qualitative study of physician user types.

Studies in health technology and informatics

Miller RH, Sim I, Newman J

EyePACS: an open source clinical communication system for eye care.

Studies in health technology and informatics

Cuadros J, Sim I

Trial bank publishing: phase I results.

Studies in health technology and informatics

Sim I, Carini S, Olasov B, Jeng S

A framework for classifying decision support systems.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Sim I, Berlin A

SysBank: a knowledge base for systematic reviews of randomized clinical trials.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Carini S, Sim I

The Trial Bank system: capturing randomized trials for evidence-based medicine.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Sim I, Olasov B, Carini S

Evidence-based practice for mere mortals: the role of informatics and health services research.

Journal of general internal medicine

Sim I, Sanders GD, McDonald KM

Antibiotic treatment of acute bronchitis in smokers: a systematic review.

Journal of general internal medicine

Linder JA, Sim I

Clinical decision support systems for the practice of evidence-based medicine.

Journal of the American Medical Informatics Association : JAMIA

Sim I, Gorman P, Greenes RA, Haynes RB, Kaplan B, Lehmann H, Tang PC

Electronic trial banks: a complementary method for reporting randomized trials.

Medical decision making : an international journal of the Society for Medical Decision Making

Sim I, Owens DK, Lavori PW, Rennels GD

Meta-analyses and large randomized, controlled trials.

The New England journal of medicine

Sim I, Lavori P

Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death.

Circulation

Sim I, McDonald KM, Lavori PW, Norbutas CM, Hlatky MA

Growing pains of meta-analysis.

BMJ (Clinical research ed.)

Sim I, Hlatky MA

A trial bank model for the publication of clinical trials.

Proceedings. Symposium on Computer Applications in Medical Care

Sim I, Rennels G

The NGF complex from the African rat Mastomys natalensis.

Neurochemical research

Burcham TS, Sim I, Bolin LM, Shooter EM

Synthesis and antiviral activity of metabolites of rimantadine.

Journal of medicinal chemistry

Manchand PS, Cerruti RL, Martin JA, Hill CH, Merrett JH, Keech E, Belshe RB, Connell EV, Sim IS

Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

Lepock JR, Cheng KH, Al-Qysi H, Sim I, Koch CJ, Kruuv J