Owen Wolkowitz, MD

Professor Emeritus
Psychiatry
+1 415 476-7433

Dr. Owen Wolkowitz is a clinical and translational research psychiatrist and Professor of Psychiatry at the University of California, San Francisco. His clinical work, teaching and research all focus on affective and anxiety disorders. He has been involved in psychiatric research for over 35 years, with an emphasis on stress-related mental illnesses such as Major Depression and PTSD, and he is presently Co-Director of the UCSF Depression Center. He obtained his MD degree from the University of Maryland and received his psychiatric residency training at Stanford University, after which he completed a fellowship in psychopharmacology research at the National Institute of Mental Health. His research focus is the identification of moderators and mediators of stress effects on psychiatric and comorbid physical health, with a goal of identifying novel targets for therapeutic intervention. He views many psychiatric illnesses not strictly as “mental illnesses” but as body-wide perturbations that affect the brain. He studies steroid and neurosteroid hormones, inflammation, oxidative stress, cell aging (such as telomeres, telomerase and epigenetic aging), metabolomics, mitochondrial physiology, neurotrophic factors, and neuroimaging as well as the roles of genetics and early life adversity. His team is now venturing into new directions in the gut microbiome and induced pluripotent stem cells in depression, the latter to predict individual patient responses to specific antidpressants. He was awarded the 2015 Academic J. Elliott Royer Award by the UCSF School of Medicine in “recognition of his significant cotributions to the advancement of Psychiatry.” He has published over 250 peer-reviewed papers and chapters, and he co-edited the American Psychiatric Press textbook on clinical psychoneuroendocrinology. His research, continuously funded by the NIMH, the US Department of Defense and private foundations since 1988, currently focuses on the possibility of accelerated biological aging in psychiatric conditions as well as “precision psychiatry.”

Publications: 

Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.

Molecular psychiatry

Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D, Hood L, Doyle FJ, Yehuda R, Marmar CR, Jett M, Hammamieh R, Mellon SH, Wolkowitz OM

Pre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors.

Molecular psychiatry

Schultebraucks K, Qian M, Abu-Amara D, Dean K, Laska E, Siegel C, Gautam A, Guffanti G, Hammamieh R, Misganaw B, Mellon SH, Wolkowitz OM, Blessing EM, Etkin A, Ressler KJ, Doyle FJ, Jett M, Marmar CR

Pre-treatment allostatic load and metabolic dysregulation predict SSRI response in major depressive disorder: a preliminary report.

Psychological medicine

Hough CM, Bersani FS, Mellon SH, Morford AE, Lindqvist D, Reus VI, Epel ES, Wolkowitz OM

A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.

Molecular psychiatry

Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D

Effect of Combat Exposure and Posttraumatic Stress Disorder on Telomere Length and Amygdala Volume.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Kang JI, Mueller SG, Wu GWY, Lin J, Ng P, Yehuda R, Flory JD, Abu-Amara D, Reus VI, Gautam A

Frailty Index as a clinical measure of biological age in psychiatry.

Journal of affective disorders

Bersani FS, Canevelli M, Cesari M, Maggioni E, Pasquini M, Wolkowitz OM, Ferracuti S, Biondi M, Bruno G

Vitamin D and inflammation in major depressive disorder.

Journal of affective disorders

Grudet C, Wolkowitz OM, Mellon SH, Malm J, Reus VI, Brundin L, Nier BM, Dhabhar FS, Hough CM, Westrin Å, Lindqvist D

Novel Pharmacological Targets for Combat PTSD-Metabolism, Inflammation, The Gut Microbiome, and Mitochondrial Dysfunction.

Military medicine

Bersani FS, Mellon SH, Lindqvist D, Kang JI, Rampersaud R, Somvanshi PR, Doyle FJ, Hammamieh R, Jett M, Yehuda R, Marmar CR, Wolkowitz OM

Improvement in indices of cellular protection after psychological treatment for social anxiety disorder.

Translational psychiatry

Månsson KNT, Lindqvist D, Yang LL, Svanborg C, Isung J, Nilsonne G, Bergman-Nordgren L, El Alaoui S, Hedman-Lagerlöf E, Kraepelien M, Högström J, Andersson G, Boraxbekk CJ, Fischer H, Lavebratt C, Wolkowitz OM, Furmark T

Association of comorbid depression with inpatient outcomes in critical limb ischemia.

Vascular medicine (London, England)

Zahner GJ, Cortez A, Duralde E, Ramirez JL, Wang S, Hiramoto J, Cohen BE, Wolkowitz OM, Arya S, Hills NK, Grenon SM

Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.

Molecular psychiatry

Dean KR, Hammamieh R, Mellon SH, Abu-Amara D, Flory JD, Guffanti G, Wang K, Daigle BJ, Gautam A, Lee I, Yang R, Almli LM, Bersani FS, Chakraborty N, Donohue D, Kerley K, Kim TK, Laska E, Young Lee M, Lindqvist D, Lori A, Lu L, Misganaw B, Muhie S, Newman J, Price ND, Qin S, Reus VI, Siegel C, Somvanshi PR, Thakur GS, Zhou Y

Accelerated aging in serious mental disorders.

Current opinion in psychiatry

Bersani FS, Mellon SH, Reus VI, Wolkowitz OM

Cortisol, moderated by age, is associated with antidepressant treatment outcome and memory improvement in Major Depressive Disorder: A retrospective analysis.

Psychoneuroendocrinology

Jain FA, Connolly CG, Reus VI, Meyerhoff DJ, Yang TT, Mellon SH, Mackin S, Hough CM, Morford A, Wolkowitz OM

Mechanistic inferences on metabolic dysfunction in PTSD from an integrated model and multi-omic analysis: Role of glucocorticoid receptor sensitivity.

American journal of physiology. Endocrinology and metabolism

Somvanshi PR, Mellon SH, Flory JD, Abu-Amara D, Consortium PSB, Wolkowitz OM, Yehuda R, Jett M, Hood L, Marmar C, Doyle FJ

Accelerating research on biological aging and mental health: Current challenges and future directions.

Psychoneuroendocrinology

Han LKM, Verhoeven JE, Tyrka AR, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Boks MP, Révész D, Mellon SH, Picard M

Metabolomic analysis of male combat veterans with post traumatic stress disorder.

PloS one

Mellon SH, Bersani FS, Lindqvist D, Hammamieh R, Donohue D, Dean K, Jett M, Yehuda R, Flory J, Reus VI, Bierer LM, Makotkine I, Abu Amara D, Henn Haase C, Coy M, Doyle FJ, Marmar C, Wolkowitz OM

Plasma serotonin levels are associated with antidepressant response to SSRIs.

Journal of affective disorders

Holck A, Wolkowitz OM, Mellon SH, Reus VI, Nelson JC, Westrin Å, Lindqvist D

Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder.

Psychiatry research

Khan MS, Wu GWY, Reus VI, Hough CM, Lindqvist D, Westrin Å, Nier BM, Wolkowitz OM, Mellon SH

Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status.

Molecular neuropsychiatry

Verhoeven JE, Yang R, Wolkowitz OM, Bersani FS, Lindqvist D, Mellon SH, Yehuda R, Flory JD, Lin J, Abu-Amara D, Makotkine I, Marmar C, Jett M, Hammamieh R

Posttraumatic stress disorder, symptoms, and white matter abnormalities among combat-exposed veterans.

Brain imaging and behavior

Aschbacher K, Mellon SH, Wolkowitz OM, Henn-Haase C, Yehuda R, Flory JD, Bierer LM, Abu-Amara D, Marmar CR, Mueller SG

Depression severity is associated with increased inflammation in veterans with peripheral artery disease.

Vascular medicine (London, England)

Hernandez NV, Ramirez JL, Khetani SA, Spaulding KA, Gasper WJ, Hiramoto J, Lindqvist D, Wolkowitz OM, Hills NK, Grenon SM, Zahner GJ

Accelerated biological aging in serious mental disorders.

World psychiatry : official journal of the World Psychiatric Association (WPA)

Wolkowitz OM

The association of comorbid depression with mortality and amputation in veterans with peripheral artery disease.

Journal of vascular surgery

Arya S, Lee S, Zahner GJ, Cohen BE, Hiramoto J, Wolkowitz OM, Khakharia A, Binney ZO, Grenon SM

Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder.

Biological psychiatry

Mellon SH, Gautam A, Hammamieh R, Jett M, Wolkowitz OM

High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression.

Journal of affective disorders

Tymofiyeva O, Henje Blom E, Ho TC, Connolly CG, Lindqvist D, Wolkowitz OM, Lin J, LeWinn KZ, Sacchet MD, Han LKM, Yuan JP, Bhandari SP, Xu D, Yang TT

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin Å, Hough CM, Lin J, Reus VI, Epel ES, Mellon SH

Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity.

Psychiatry research

Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM

Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings.

Journal of psychosomatic research

Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM

Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder.

Journal of affective disorders

Steenkamp LR, Hough CM, Reus VI, Jain FA, Epel ES, James SJ, Morford AE, Mellon SH, Wolkowitz OM, Lindqvist D

Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans.

Psychoneuroendocrinology

Blessing EM, Reus V, Mellon SH, Wolkowitz OM, Flory JD, Bierer L, Lindqvist D, Dhabhar F, Li M, Qian M, Abu-Amara D, Galatzer-Levy I, Yehuda R, Marmar CR

Higher serum DHEA concentrations before and after SSRI treatment are associated with remission of major depression.

Psychoneuroendocrinology

Hough CM, Lindqvist D, Epel ES, Denis MS, Reus VI, Bersani FS, Rosser R, Mahan L, Burke HM, Wolkowitz OM, Mellon SH

Oxidative stress, inflammation and treatment response in major depression.

Psychoneuroendocrinology

Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH

Unresolved Issues in Longitudinal Telomere Length Research: Response to Susser et al.

The American journal of psychiatry

Verhoeven JE, Lin J, Révész D, Wolkowitz OM, Penninx BW

Leukocyte telomere length: Effects of schizophrenia, age, and gender.

Journal of psychiatric research

Wolkowitz OM, Jeste DV, Martin AS, Lin J, Daly RE, Reuter C, Kraemer H

Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study.

Brain, behavior, and immunity

Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM

The Association Between Psychiatric Disorders and Telomere Length: A Meta-Analysis Involving 14,827 Persons.

Psychosomatic medicine

Darrow SM, Verhoeven JE, Révész D, Lindqvist D, Penninx BW, Delucchi KL, Wolkowitz OM, Mathews CA

Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls.

Psychoneuroendocrinology

Jin RO, Mason S, Mellon SH, Epel ES, Reus VI, Mahan L, Rosser RL, Hough CM, Burke HM, Mueller SG, Wolkowitz OM

Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report.

Molecular neuropsychiatry

Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM

Elevated plasma F2-isoprostane levels in schizophrenia.

Schizophrenia research

Lee EE, Eyler LT, Wolkowitz OM, Martin AS, Reuter C, Kraemer H, Jeste DV

A population of atypical CD56(-)CD16(+) natural killer cells is expanded in PTSD and is associated with symptom severity.

Brain, behavior, and immunity

Bersani FS, Wolkowitz OM, Milush JM, Sinclair E, Eppling L, Aschbacher K, Lindqvist D, Yehuda R, Flory J, Bierer LM, Matokine I, Abu-Amara D, Reus VI, Coy M, Hough CM, Marmar CR, Mellon SH

Depressive and Anxiety Disorders Showing Robust, but Non-Dynamic, 6-Year Longitudinal Association With Short Leukocyte Telomere Length.

The American journal of psychiatry

Verhoeven JE, van Oppen P, Révész D, Wolkowitz OM, Penninx BW

Association of dimensional psychological health measures with telomere length in male war veterans.

Journal of affective disorders

Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM

Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.

Brain, behavior, and immunity

Bersani FS, Wolkowitz OM, Lindqvist D, Yehuda R, Flory J, Bierer LM, Makotine I, Abu-Amara D, Coy M, Reus VI, Epel ES, Marmar C, Mellon SH

Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder.

Psychiatry research

Mueller SG, Ng P, Neylan T, Mackin S, Wolkowitz O, Mellon S, Yan X, Flory J, Yehuda R, Marmar CR, Weiner MW

Telomerase activation as a possible mechanism of action for psychopharmacological interventions.

Drug discovery today

Bersani FS, Lindqvist D, Mellon SH, Penninx BW, Verhoeven JE, Révész D, Reus VI, Wolkowitz OM

Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.

Progress in neuro-psychopharmacology & biological psychiatry

Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH

A Preliminary Study: Efficacy of Mindfulness-Based Cognitive Therapy versus Sertraline as First-line Treatments for Major Depressive Disorder.

Mindfulness

Eisendrath SJ, Gillung E, Delucchi K, Mathalon DH, Yang TT, Satre DD, Rosser R, Sipe WE, Wolkowitz OM

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.

Neuroscience and biobehavioral reviews

Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM

Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Lohr JB, Palmer BW, Eidt CA, Aailaboyina S, Mausbach BT, Wolkowitz OM, Thorp SR, Jeste DV

Anxiety disorders and accelerated cellular ageing.

The British journal of psychiatry : the journal of mental science

Verhoeven JE, Révész D, van Oppen P, Epel ES, Wolkowitz OM, Penninx BW

PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.

Psychiatry research

Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S

WITHDRAWN: Precuneal and amygdala spontaneous activity and functional connectivity in war-zone-related PTSD.

Psychiatry research

Yan X, Lazar M, Shalev AY, Neylan TC, Wolkowitz OM, Brown AD, Henn-Haase C, Yehuda R, Flory JD, Abu-Amara D, Sodickson DK, Marmar CR

Adverse consequences of glucocorticoid medication: psychological, cognitive, and behavioral effects.

The American journal of psychiatry

Judd LL, Schettler PJ, Brown ES, Wolkowitz OM, Sternberg EM, Bender BG, Bulloch K, Cidlowski JA, de Kloet ER, Fardet L, Joëls M, Leung DY, McEwen BS, Roozendaal B, Van Rossum EF, Ahn J, Brown DW, Plitt A, Singh G

Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings.

Psychiatry research

Lindqvist D, Mueller S, Mellon SH, Su Y, Epel ES, Reus VI, Rosser R, Mahan L, Mackin RS, Yang TT, Wolkowitz OM

Cellular aging in depression: Permanent imprint or reversible process?: An overview of the current evidence, mechanistic pathways, and targets for interventions.

BioEssays : news and reviews in molecular, cellular and developmental biology

Verhoeven JE, Révész D, Wolkowitz OM, Penninx BW

Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults.

Journal of affective disorders

Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM

Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress.

Brain, behavior, and immunity

Lindqvist D, Wolkowitz OM, Mellon S, Yehuda R, Flory JD, Henn-Haase C, Bierer LM, Abu-Amara D, Coy M, Neylan TC, Makotkine I, Reus VI, Yan X, Taylor NM, Marmar CR, Dhabhar FS

Dysregulated physiological stress systems and accelerated cellular aging.

Neurobiology of aging

Révész D, Verhoeven JE, Milaneschi Y, de Geus EJ, Wolkowitz OM, Penninx BW

Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents.

Biological psychiatry

Connolly CG, Wu J, Ho TC, Hoeft F, Wolkowitz O, Eisendrath S, Frank G, Hendren R, Max JE, Paulus MP, Tapert SF, Banerjee D, Simmons AN, Yang TT

Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression.

Journal of the American Academy of Child and Adolescent Psychiatry

Ho TC, Wu J, Shin DD, Liu TT, Tapert SF, Yang G, Connolly CG, Frank GK, Max JE, Wolkowitz O, Eisendrath S, Hoeft F, Banerjee D, Hood K, Hendren RL, Paulus MP, Simmons AN, Yang TT

Spontaneous brain activity in combat related PTSD.

Neuroscience letters

Yan X, Brown AD, Lazar M, Cressman VL, Henn-Haase C, Neylan TC, Shalev A, Wolkowitz OM, Hamilton SP, Yehuda R, Sodickson DK, Weiner MW, Marmar CR

Stress and telomere biology: a lifespan perspective.

Psychoneuroendocrinology

Shalev I, Entringer S, Wadhwa PD, Wolkowitz OM, Puterman E, Lin J, Epel ES

Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity.

Psychoneuroendocrinology

Aschbacher K, O'Donovan A, Wolkowitz OM, Dhabhar FS, Su Y, Epel E

Dysregulated diurnal cortisol pattern is associated with glucocorticoid resistance in women with major depressive disorder.

Biological psychology

Jarcho MR, Slavich GM, Tylova-Stein H, Wolkowitz OM, Burke HM

BDNF serum concentrations show no relationship with diagnostic group or medication status in neurodegenerative disease.

Current Alzheimer research

Woolley JD, Strobl EV, Shelly WB, Karydas AM, Robin Ketelle RN, Wolkowitz OM, Miller BL, Rankin KP

Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length.

Brain, behavior, and immunity

O'Donovan A, Tomiyama AJ, Lin J, Puterman E, Adler NE, Kemeny M, Wolkowitz OM, Blackburn EH, Epel ES

Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length.

Physiology & behavior

Tomiyama AJ, O'Donovan A, Lin J, Puterman E, Lazaro A, Chan J, Dhabhar FS, Wolkowitz O, Kirschbaum C, Blackburn E, Epel E

Higher fasting glucose levels are associated with reduced circulating angiogenic cell migratory capacity among healthy individuals.

American journal of cardiovascular disease

Aschbacher K, Chen Q, Varga M, Haddad DJ, Yeghiazarians Y, Epel E, Wolkowitz OM, Springer ML

Physical activity moderates effects of stressor-induced rumination on cortisol reactivity.

Psychosomatic medicine

Puterman E, O'Donovan A, Adler NE, Tomiyama AJ, Kemeny M, Wolkowitz OM, Epel E

Serum BDNF levels before treatment predict SSRI response in depression.

Progress in neuro-psychopharmacology & biological psychiatry

Wolkowitz OM, Wolf J, Shelly W, Rosser R, Burke HM, Lerner GK, Reus VI, Nelson JC, Epel ES, Mellon SH

Divergent trajectories of physical, cognitive, and psychosocial aging in schizophrenia.

Schizophrenia bulletin

Jeste DV, Wolkowitz OM, Palmer BW

Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder.

Biological psychiatry

O'Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S, Metzler T, Lenoci M, Blackburn E, Neylan TC

Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.

PloS one

Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, Blackburn EH

Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.

Molecular psychiatry

Wolkowitz OM, Mellon SH, Epel ES, Lin J, Reus VI, Rosser R, Burke H, Compagnone M, Nelson JC, Dhabhar FS, Blackburn EH

Of sound mind and body: depression, disease, and accelerated aging.

Dialogues in clinical neuroscience

Wolkowitz OM, Reus VI, Mellon SH

Intensive meditation training, immune cell telomerase activity, and psychological mediators.

Psychoneuroendocrinology

Jacobs TL, Epel ES, Lin J, Blackburn EH, Wolkowitz OM, Bridwell DA, Zanesco AP, Aichele SR, Sahdra BK, MacLean KA, King BG, Shaver PR, Rosenberg EL, Ferrer E, Wallace BA, Saron CD

Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline.

Brain research

Lin J, Kroenke CH, Epel E, Kenna HA, Wolkowitz OM, Blackburn E, Rasgon NL

Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder.

Progress in neuro-psychopharmacology & biological psychiatry

Berger W, Mehra A, Lenoci M, Metzler TJ, Otte C, Tarasovsky G, Mellon SH, Wolkowitz OM, Marmar CR, Neylan TC

Depression gets old fast: do stress and depression accelerate cell aging?

Depression and anxiety

Wolkowitz OM, Epel ES, Reus VI, Mellon SH

Dynamics of telomerase activity in response to acute psychological stress.

Brain, behavior, and immunity

Epel ES, Lin J, Dhabhar FS, Wolkowitz OM, Puterman E, Karan L, Blackburn EH

Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.

Journal of immunological methods

Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E

Glucocorticoids. Mood, memory, and mechanisms.

Annals of the New York Academy of Sciences

Wolkowitz OM, Burke H, Epel ES, Reus VI

Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression.

Journal of psychiatric research

Dhabhar FS, Burke HM, Epel ES, Mellon SH, Rosser R, Reus VI, Wolkowitz OM

Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?

Biological psychiatry

Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).

Frontiers in neuroendocrinology

Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH

When blue turns to grey: do stress and depression accelerate cell aging?

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Wolkowitz OM, Epel ES, Mellon S

Catecholamine response to methamphetamine is related to glucocorticoid levels but not to pleasurable subjective response.

Pharmacopsychiatry

Harris DS, Reus VI, Wolkowitz O, Jacob P, Everhart ET, Wilson M, Mendelson JE, Jones RT

Cell aging in relation to stress arousal and cardiovascular disease risk factors.

Psychoneuroendocrinology

Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE, Dolbier C, Mendes WB, Blackburn EH

Repeated psychological stress testing in stimulant-dependent patients.

Progress in neuro-psychopharmacology & biological psychiatry

Harris DS, Reus VI, Wolkowitz OM, Mendelson JE, Jones RT

The "steroid dementia syndrome": an unrecognized complication of glucocorticoid treatment.

Annals of the New York Academy of Sciences

Wolkowitz OM, Lupien SJ, Bigler E, Levin RB, Canick J

Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation.

Psychoneuroendocrinology

Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM

Behavioral implications of lowering cholesterol levels: a double-blind pilot study.

Psychosomatics

Ormiston T, Wolkowitz OM, Reus VI, Manfredi F

Neurotransmitters, neurosteroids and neurotrophins: new models of the pathophysiology and treatment of depression.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Wolkowitz OM, Reus VI

Altering cortisol level does not change the pleasurable effects of methamphetamine in humans.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Harris DS, Reus VI, Wolkowitz OM, Mendelson JE, Jones RT

Benzodiazepines in schizophrenia: prefrontal cortex atrophy predicts clinical response to alprazolam augmentation.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Seeley WW, Turetsky N, Reus VI, Wolkowitz OM

Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot study.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Marco EJ, Wolkowitz OM, Vinogradov S, Poole JH, Lichtmacher J, Reus VI

Dehydroepiandrosterone supplementation and bone turnover in middle-aged to elderly men.

The Journal of clinical endocrinology and metabolism

Kahn AJ, Halloran B, Wolkowitz O, Brizendine L

Serotonergic intervention increases affiliative behavior in humans.

Annals of the New York Academy of Sciences

Knutson B, Cole S, Wolkowitz O, Reus V, Chan T, Moore E

The effects of clozapine on symptom reduction, neurocognitive function, and clinical management in treatment-refractory state hospital schizophrenic inpatients.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Hoff AL, Faustman WO, Wieneke M, Espinoza S, Costa M, Wolkowitz O, Csernansky JG

Beneficial effects of nalmefene augmentation in neuroleptic-stabilized schizophrenic patients.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Rapaport MH, Wolkowitz O, Kelsoe JR, Pato C, Konicki PE, Pickar D

The corticotropin-releasing hormone stimulation test in chronic schizophrenia.

The American journal of psychiatry

Roy A, Pickar D, Doran A, Wolkowitz O, Gallucci W, Chrousos G, Gold P

Benzodiazepine sensitivity in normal human subjects.

Archives of general psychiatry

Hommer DW, Matsuo V, Wolkowitz O, Chrousos G, Greenblatt DJ, Weingartner H, Paul SM