Suzaynn Schick, PhD

Assistant Adjunct Professor
Medicine
+1 415 206-5904

I study the health effects of air pollution in human subjects. I focus on the chemistry and toxicity of smoke and on how smoking and using electronic cigarettes can cause heart and lung disease. My analysis of tobacco industry research showed that sidestream cigarette smoke (the primary constituent of secondhand cigarette smoke) is more toxic than the smoke that smokers inhale and that secondhand smoke becomes more toxic as it ages.

I have published three controlled human exposure studies on the health effects of secondhand cigarette smoke which show that:
1. A single 30-minute exposure to fresh sidestream cigarette smoke, at 350 micrograms of particles per cubic meter, decreases flow-mediated dilation of the brachial artery and increases plasma VEGF and endothelial progenitor cell motility. (These changes can increase the risk of heart attack.)
2. For each increase in SHS exposure by 100 µg/m3 particles, the absolute maximal percent brachial artery flow-mediated dilation was reduced by 0.67%. (Even a little smoke can increase the risk of heart disease.)
3. A single 30-minute exposure to aged cigarette smoke, at 1000 µg/m3 particles, increases nasal congestion in healthy human subjects. (Nasal congestion can lead to sinus infections.)

My research on the chemistry and toxicity of cigarette smoke has helped define a new health risk from smoking: thirdhand cigarette smoke. Thirdhand smoke is the tiny droplets of oils and waxes (tar) that stick to surfaces, like walls, furniture, clothing and hair. Thirdhand smoke cannot be removed by ventilation. Many of the toxins and carcinogens in smoke linger for days, months and years after the cigarettes are gone. My laboratory is funded by the California Tobacco-Related Disease Research Program to study how humans absorb thirdhand smoke from the environment. My laboratory is also funded by the FDA and the NIH to study the cardiovascular effects of tobacco and nicotine delivery products. I am member of the California Thirdhand Smoke Consortium, the UCSF Helen Diller Family Comprehensive Cancer Center and the UCSF Center for Tobacco Control Research and Education. My goals are to understand how smoke causes heart attacks and respiratory disease and to educate society on the true impact that air pollution has on human health.

Publications: 

Biomarkers of Exposure to New and Emerging Tobacco and Nicotine Delivery Products.

American journal of physiology. Lung cellular and molecular physiology

Schick SF, Blount BC, Jacob P, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, Srivastava S, St Helen G, Tarran R, Lorkiewicz PK, Blair IA, Kimmel HL, Doerschuk CM, Benowitz NL, Bhatnagar A

Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice.

Scientific reports

Hang B, Snijders AM, Huang Y, Schick SF, Wang P, Xia Y, Havel C, Jacob P, Benowitz N, Destaillats H, Gundel LA, Mao JH

Thirdhand Smoke: New Evidence, Challenges, and Future Directions.

Chemical research in toxicology

Jacob P, Benowitz NL, Destaillats H, Gundel L, Hang B, Martins-Green M, Matt GE, Quintana PJ, Samet JM, Schick SF, Talbot P, Aquilina NJ, Hovell MF, Mao JH, Whitehead TP

One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function.

Journal of the American Heart Association

Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML

Thirdhand Cigarette Smoke Causes Stress-Induced Mitochondrial Hyperfusion and Alters the Transcriptional Profile of Stem Cells.

Toxicological sciences : an official journal of the Society of Toxicology

Bahl V, Johnson K, Phandthong R, Zahedi A, Schick SF, Talbot P

Corrigendum: Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke.

Scientific reports

Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF, Mao JH, Hang B, Xia Y

Impairment of Endothelial Function by Little Cigar Secondhand Smoke.

Tobacco regulatory science

Liu J, Wang X, Narayan S, Glantz SA, Schick SF, Springer ML

Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation.

Toxicological sciences : an official journal of the Society of Toxicology

Bahl V, Weng NJ, Schick SF, Sleiman M, Whitehead J, Ibarra A, Talbot P

Thirdhand smoke: Chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments.

Toxicology in vitro : an international journal published in association with BIBRA

Bahl V, Shim HJ, Jacob P, Dias K, Schick SF, Talbot P

Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke.

Scientific reports

Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF, Mao JH, Hang B, Xia Y

Correction: A novel minimally-invasive method to sample human endothelial cells for molecular profiling.

PloS one

Waldo SW, Brenner DA, McCabe JM, Cruz MD, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY

A novel minimally-invasive method to sample human endothelial cells for molecular profiling.

PloS one

Waldo SW, Brenner DA, McCabe JM, Dela Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY

Thirdhand cigarette smoke: factors affecting exposure and remediation.

PloS one

Bahl V, Jacob P, Havel C, Schick SF, Talbot P

Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Pinnamaneni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML

Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke.

Chemical research in toxicology

Jacob P, Goniewicz ML, Havel CM, Schick SF, Benowitz NL

Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK.

Tobacco control

Schick SF, Farraro KF, Perrino C, Sleiman M, van de Vossenberg G, Trinh MP, Hammond SK, Jenkins BM, Balmes J

Thirdhand smoke causes DNA damage in human cells.

Mutagenesis

Hang B, Sarker AH, Havel C, Saha S, Hazra TK, Schick S, Jacob P, Rehan VK, Chenna A, Sharan D, Sleiman M, Destaillats H, Gundel LA

Thirty minute-exposure to aged cigarette smoke increases nasal congestion in nonsmokers.

Journal of toxicology and environmental health. Part A

Schick SF, van den Vossenberg G, Luo A, Whitlatch A, Jacob P, Balmes J, Shusterman D

Aerosol Science and Technology

An Apparatus for Generating Aged Cigarette Smoke for Controlled Human Exposure Studies

Suzaynn F. Schick, Kathryn F. Farraro, Jiaxi Fang, Sarah Nasir, Justin Kim,
Donald Lucas, Hofer Wong, John Balmes, D. Ken Giles, and Bryan Jenkins

The exposure-dependent effects of aged secondhand smoke on endothelial function.

Journal of the American College of Cardiology

Frey PF, Ganz P, Hsue PY, Benowitz NL, Glantz SA, Balmes JR, Schick SF

Pilot evaluation of the nasal nitric oxide response to humming as an index of osteomeatal patency.

American journal of rhinology & allergy

Shusterman DJ, Weaver EM, Goldberg AN, Schick SF, Wong HH, Balmes JR

Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda.

Environmental health perspectives

Matt GE, Quintana PJ, Destaillats H, Gundel LA, Sleiman M, Singer BC, Jacob P, Benowitz N, Winickoff JP, Rehan V, Talbot P, Schick S, Samet J, Wang Y, Hang B, Martins-Green M, Pankow JF, Hovell MF

Thirdhand smoke: here to stay.

Tobacco control

Schick SF, Schick S

Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production.

Journal of the American College of Cardiology

Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y

Pilot study of compliance with healthcare facility smoking laws in Georgia.

Georgian medical news

Schick S, Gvinianidze K, Tsereteli D, Novotny T, Hammond K

The tobacco industry and the Data Quality Act.

Science (New York, N.Y.)

Schick SF, Bero LA, Cook DM

Concentrations of the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in sidestream cigarette smoke increase after release into indoor air: results from unpublished tobacco industry research.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Schick SF, Glantz S

Scientific analysis of second-hand smoke by the tobacco industry, 1929-1972.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Schick S, Glantz S

Implications of ASHRAE's guidelines for ventilation in smoking permitted areas

ASHRAE Journal

Glantz, Stanton A
Schick, Suzaynn F

Adhesive interactions in peri-implantation morphogenesis and placentation.

Reproductive toxicology (Elmsford, N.Y.)

Damsky Ch, Schick SF, Klimanskaya I, Stephens L, Zhou Y, Fisher S