Jacqueline Leung, MD, MPH

Professor Emeritus
Anesthesia
[email protected]
+1 415 476-0711

Dr. Leung is the director of the Perioperative Medicine Research Group based at UCSF Medical Center. The group conducts outcomes research in older surgical patients. Our recent work focuses on identifying the pathophysiology of postoperative delirium and cognitive decline, and also the mechanism between sleep disruption and ICU delirium.

Publications: 

2025 American Society of Anesthesiologists Practice Advisory for Perioperative Care of Older Adults Scheduled for Inpatient Surgery.

Anesthesiology

Sieber F, McIsaac DI, Deiner S, Azefor T, Berger M, Hughes C, Leung JM, Maldon J, McSwain JR, Neuman MD, Russell MM, Tang V, Whitlock E, Whittington R, Marbella AM, Agarkar M, Ramirez S, Dyer A, Friel Blanck J, Uhl S, Grant MD, Domino KB

Multi-level social determinants of health, inflammation, and postoperative delirium in older adults.

Journal of the American Geriatrics Society

Vasunilashorn SM, Wolfson E, Berger M, Leung J, Ware EB, Baccarelli A, Jones RN, Ngo LH, Marcantonio ER, Inouye SK, Kind AJH

Plasma SOMAmer proteomics of postoperative delirium.

Brain and Behavior

Leung JM, Rojas JC, Sands LP, Chan B, Rajbanshi B, Du Z, Du P, Perioperative Medicine Research group

Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals.

Frontiers in immunology

Leung JM, Wu MJ, Kheradpour P, Chen C, Drake KA, Tong G, Ridaura VK, Zisser HC, Conrad WA, Hudson N, Allen J, Welberry C, Parsy-Kowalska C, Macdonald I, Tapson VF, Moy JN, deFilippi CR, Rosas IO, Basit M, Krishnan JA, Parthasarathy S, Prabhakar BS, Salvatore M, Kim CC

Assessing patterns of delirium symptoms reveals a novel subtype among elective surgical patients with postoperative delirium.

International journal of geriatric psychiatry

Yang L, Do Q, Zhu X, Leung JM, Perioperative Medicine Research Group, Sands LP

Distinct temporal trajectories and risk factors for Post-acute sequelae of SARS-CoV-2 infection.

Frontiers in medicine

Chen C, Parthasarathy S, Leung JM, Wu MJ, Drake KA, Ridaura VK, Zisser HC, Conrad WA, Tapson VF, Moy JN, deFilippi CR, Rosas IO, Prabhakar BS, Basit M, Salvatore M, Krishnan JA, Kim CC

Multi-omic profiling reveals early immunological indicators for identifying COVID-19 Progressors.

Clinical immunology (Orlando, Fla.)

Drake KA, Talantov D, Tong GJ, Lin JT, Verheijden S, Katz S, Leung JM, Yuen B, Krishna V, Wu MJ, Sutherland A, Short SA, Kheradpour P, Mumbach M, Franz KM, Trifonov V, Lucas MV, Merson J, Kim CC, PRESCO Study Group

The presence of preoperative neurodegeneration biofluid markers in patients with postoperative delirium.

Anesthesiology

Leung JM, Rojas JC, Tang C, Chan B, Lario-Lago A, Boxer AL, Do Q, Kramer JH, Du Z, Du P, Sands LP, and the Perioperative Medicine Research group1 *

Fine structure and molecular characterization of two new parabasalid species that naturally colonize laboratory mice, Tritrichomonas musculus and Tritrichomonas casperi.

The Journal of eukaryotic microbiology

Tuzlak L, Alves-Ferreira EVC, Schwartz CL, Kennard A, Leung JM, Shehata C, Grigg ME

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.

Nature communications

Robertson SJ, Bedard O, McNally KL, Shaia C, Clancy CS, Lewis M, Broeckel RM, Chiramel AI, Shannon JG, Sturdevant GL, Rosenke R, Anzick SL, Forte E, Preuss C, Baker CN, Harder JM, Brunton C, Munger S, Bruno DP, Lack JB, Leung JM, Shamsaddini A, Gardina P, Sturdevant DE, Sun J, Martens C, Holland SM, Rosenthal NA, Best SM

Multi-omic Profiling Reveals Early Immunological Indicators for Identifying COVID-19 Progressors.

bioRxiv : the preprint server for biology

Drake KA, Talantov D, Tong GJ, Lin JT, Verheijden S, Katz S, Leung JM, Yuen B, Krishna V, Wu MJ, Sutherland A, Short SA, Kheradpour P, Mumbach M, Franz K, Trifonov V, Lucas MV, Merson J, Kim CC, PRESCO Study Group

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.

bioRxiv : the preprint server for biology

Robertson S, Bedard O, McNally K, Shaia C, Clancy C, Lewis M, Broeckel R, Chiramel A, Shannon JG, Sturdevant G, Rosenke R, Anzick SL, Forte E, Preuss C, Baker C, Harder J, Brunton C, Munger SC, Bruno DP, Lack JB, Leung JM, Shamsaddini A, Gardina P, Sturdevant D, Sun J, Martens C, Holland S, Rosenthal N, Best S

Sleep Loss the night before surgery and incidence of postoperative delirium in adults 65-95 years of age.

Sleep medicine

Leung JM, Tang C, Do Q, Sands LP, Tran D, Lee KA, Perioperative Medicine Research Group

Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge.

EBioMedicine

Leventhal SS, Meade-White K, Rao D, Haddock E, Leung J, Scott D, Archer J, Randall S, Erasmus JH, Feldmann H, Hawman DW

KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients.

Scientific reports

Terrelonge M, LaHue SC, Tang C, Movsesyan I, Pullinger CR, Dubal DB, Leung J, Douglas VC

Postoperative delirium prediction using machine learning models and preoperative electronic health record data.

BMC anesthesiology

Bishara A, Chiu C, Whitlock EL, Douglas VC, Lee S, Butte AJ, Leung JM, Donovan AL

A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis.

PLoS pathogens

Broeckel RM, Feldmann F, McNally KL, Chiramel AI, Sturdevant GL, Leung JM, Hanley PW, Lovaglio J, Rosenke R, Scott DP, Saturday G, Bouamr F, Rasmussen AL, Robertson SJ, Best SM

Further Insight into the Mechanism of Human PMN Lysis following Phagocytosis of Staphylococcus aureus.

Microbiology spectrum

Rungelrath V, Porter AR, Malachowa N, Freedman BA, Leung JM, Voyich JM, Otto M, Kobayashi SD, DeLeo FR

Rottlerin inhibits La Crosse virus-induced encephalitis in mice and blocks release of replicating virus from the Golgi body in neurons.

Nature microbiology

Ojha D, Winkler CW, Leung JM, Woods TA, Chen CZ, Nair V, Taylor K, Yeh CD, Tawa GJ, Larson CL, Zheng W, Haigh CL, Peterson KE

Midazolam Premedication Immediately Before Surgery Is Not Associated With Early Postoperative Delirium.

Anesthesia and analgesia

Wang ML, Min J, Sands LP, Leung JM, Perioperative Medicine Research Group

The Impact of Surgery duration and Surgery End Time on Postoperative Sleep in Older Adults.

Journal of sleep disorders and management

Tran D, Tang C, Tabatabai S, Pleasants D, Choukalas C, Min J, Do Q, Sands L, Lee K, Leung JM

Obesity and perioperative outcomes in older surgical patients undergoing elective spine and major arthroplasty surgery.

Journal of clinical anesthesia

Tabatabai S, Do Q, Min J, Tang CJ, Pleasants D, Sands LP, Du P, Leung JM

ADAPT-2: A Randomized Clinical Trial to Reduce Intraoperative EEG Suppression in Older Surgical Patients Undergoing Major Noncardiac Surgery.

Anesthesia and analgesia

Tang CJ, Jin Z, Sands LP, Pleasants D, Tabatabai S, Hong Y, Leung JM

American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Delirium Prevention.

Anesthesia and analgesia

Hughes CG, Boncyk CS, Culley DJ, Fleisher LA, Leung JM, McDonagh DL, Gan TJ, McEvoy MD, Miller TE

ADAPT-2: A Randomized Clinical Trial to Reduce Intraoperative EEG Suppression in Older Surgical Patients Undergoing Major Noncardiac Surgery.

Anesthesia and analgesia

Tang CJ, Jin Z, Sands LP, Pleasants D, Tabatabai S, Hong Y, Leung JM

Volatile anaesthetics and postoperative delirium in older surgical patients-A secondary analysis of prospective cohort studies.

Acta anaesthesiologica Scandinavica

Kinjo S, Lim E, Magsaysay MV, Sands LP, Leung JM

Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial.

Anesthesiology

Leung JM, Sands LP, Chen N, Ames C, Berven S, Bozic K, Burch S, Chou D, Covinsky K, Deviren V, Kinjo S, Kramer JH, Ries M, Tay B, Vail T, Weinstein P, Chang S, Meckler G, Newman S, Tsai T, Voss V, Youngblom E

Validation of a Nurse-Based Delirium-Screening Tool for Hospitalized Patients.

Psychosomatics

Hargrave A, Bastiaens J, Bourgeois JA, Neuhaus J, Josephson SA, Chinn J, Lee M, Leung J, Douglas V

Preoperative Sleep Disruption and Postoperative Delirium.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Leung JM, Sands LP, Newman S, Meckler G, Xie Y, Gay C, Lee K

Prognostic Significance of Postoperative Subsyndromal Delirium.

Psychosomatics

Shim J, DePalma G, Sands LP, Leung JM

Sensitivity and specificity of the animal fluency test for predicting postoperative delirium.

Canadian journal of anaesthesia = Journal canadien d'anesthesie

Long LS, Wolpaw JT, Leung JM

The temporal relationship between early postoperative delirium and postoperative cognitive dysfunction in older patients: a prospective cohort study.

Canadian journal of anaesthesia = Journal canadien d'anesthesie

Youngblom E, DePalma G, Sands L, Leung J

Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium?

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Leung JM, Sands LP, Lim E, Tsai TL, Kinjo S

Association between intraoperative blood transfusions and early postoperative delirium in older adults.

Journal of the American Geriatrics Society

Behrends M, DePalma G, Sands L, Leung J

Impact of missing data on analysis of postoperative cognitive decline (POCD).

Applied nursing research : ANR

DeCrane SK, Sands LP, Young KM, DePalma G, Leung JM

An update on delirium in the postoperative setting: prevention, diagnosis and management.

Best practice & research. Clinical anaesthesiology

Shim JJ, Leung JM

A brief review of practical preoperative cognitive screening tools.

Canadian journal of anaesthesia = Journal canadien d'anesthesie

Long LS, Shapiro WA, Leung JM

Does using a femoral nerve block for total knee replacement decrease postoperative delirium?

BMC anesthesiology

Kinjo S, Lim E, Sands LP, Bozic KJ, Leung JM

Prediction of postoperative pain using path analysis in older patients.

Journal of anesthesia

Kinjo S, Sands LP, Lim E, Paul S, Leung JM

Perioperative cognitive decline in the aging population.

Mayo Clinic proceedings

Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M

Factors associated with recovery from early postoperative delirium.

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

DeCrane SK, Sands L, Ashland M, Lim E, Tsai TL, Paul S, Leung JM

Postoperative delirium: are there modifiable risk factors?

European journal of anaesthesiology

Leung JM

Does postoperative delirium limit the use of patient-controlled analgesia in older surgical patients?

Anesthesiology

Leung JM, Sands LP, Paul S, Joseph T, Kinjo S, Tsai T

The effects of postoperative pain and its management on postoperative cognitive dysfunction.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Wang Y, Sands LP, Vaurio L, Mullen EA, Leung JM

Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.

Neurology

Leung JM, Sands LP, Rico M, Petersen KL, Rowbotham MC, Dahl JB, Ames C, Chou D, Weinstein P

Postoperative delirium: the importance of pain and pain management.

Anesthesia and analgesia

Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung JM

Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients?

The journals of gerontology. Series A, Biological sciences and medical sciences

Leung JM, Sands LP, Mullen EA, Wang Y, Vaurio L

Post-CABG dobutamine stress echocardiography.

Anesthesia and analgesia

Leung JM, Bellows WH

Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery.

Anesthesia and analgesia

Chandy J, Nakai T, Lee RJ, Bellows WH, Dzankic S, Leung JM

The prevalence of preoperative diastolic filling abnormalities in geriatric surgical patients.

Anesthesia and analgesia

Phillip B, Pastor D, Bellows W, Leung JM

Comparison of left atrial dimensions by transesophageal and transthoracic echocardiography.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Block M, Hourigan L, Bellows WH, Reeves J, Romson JL, Tran M, Pastor D, Schiller NB, Leung JM

The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery.

American heart journal

Nakai T, Lee RJ, Schiller NB, Bellows WH, Dzankic S, Reeves J, Romson J, Ferguson S, Leung JM

Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans.

Anesthesiology

Leung JM, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P

Predicting adverse postoperative outcomes in patients aged 80 years or older.

Journal of the American Geriatrics Society

Liu LL, Leung JM

Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(-1) x min(-1).

Anesthesiology

Lieberman JA, Weiskopf RB, Kelley SD, Feiner J, Noorani M, Leung J, Toy P, Viele M

Effects of dobutamine on hemodynamics and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients.

Anesthesiology

Romson JL, Leung JM, Bellows WH, Bronstein M, Keith F, Moores W, Flachsbart K, Richter R, Pastor D, Fisher DM

Automated electrocardiograph ST segment trending monitors: accuracy in detecting myocardial ischemia.

Anesthesia and analgesia

Leung JM, Voskanian A, Bellows WH, Pastor D

Dissociation between haemodynamics and sympathetic activation during anaesthetic induction with desfluranes.

Canadian journal of anaesthesia = Journal canadien d'anesthesie

Leung JM, Pastor DA

Human cardiovascular and metabolic response to acute, severe isovolemic anemia.

JAMA

Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA

Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization.

The Journal of thoracic and cardiovascular surgery

Hennein HA, Ebba H, Rodriguez JL, Merrick SH, Keith FM, Bronstein MH, Leung JM, Mangano DT, Greenfield LJ, Rankin JS

An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. SPI Research Group.

Anesthesia and analgesia

Leung JM, Stanley T, Mathew J, Curling P, Barash P, Salmenpera M, Reves JG, Hollenberg M, Mangano DT

Effects of steal-prone anatomy on intraoperative myocardial ischemia. The SPI Research Group.

Journal of the American College of Cardiology

Leung JM, Hollenberg M, O'Kelly BF, Kao A, Mangano DT

The risk of myocardial ischemia in patients receiving desflurane versus sufentanil anesthesia for coronary artery bypass graft surgery. The S.P.I. Research Group.

Anesthesiology

Helman JD, Leung JM, Bellows WH, Pineda N, Roach GW, Reeves JD, Howse J, McEnany MT, Mangano DT

Postoperative myocardial ischemia. Therapeutic trials using intensive analgesia following surgery. The Study of Perioperative Ischemia (SPI) Research Group.

Anesthesiology

Mangano DT, Siliciano D, Hollenberg M, Leung JM, Browner WS, Goehner P, Merrick S, Verrier E

The role of hemodynamics in perioperative myocardial ischemia.

International anesthesiology clinics

Leung JM

Transesophageal echocardiographic assessment of left ventricular function.

International journal of cardiac imaging

Leung JM, Schiller NB, Mangano DT