Jacqueline Leung, MD

+1 415 476-0711

Dr. Leung is the director of the Perioperative Medicine Research Group based at UCSF Medical Center. The group conducts outcomes research in older surgical patients. Our recent work focuses on identifying the pathophysiology of postoperative delirium and cognitive decline, and also the mechanism between sleep disruption and ICU delirium.


Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial.


Leung JM, Sands LP, Chen N, Ames C, Berven S, Bozic K, Burch S, Chou D, Covinsky K, Deviren V, Kinjo S, Kramer JH, Ries M, Tay B, Vail T, Weinstein P, Chang S, Meckler G, Newman S, Tsai T, Voss V, Youngblom E

Integrated Analysis of Biopsies from Inflammatory Bowel Disease Patients Identifies SAA1 as a Link Between Mucosal Microbes with TH17 and TH22 Cells.

Inflammatory bowel diseases

Tang MS, Bowcutt R, Leung JM, Wolff MJ, Gundra UM, Hudesman D, Malter LB, Poles MA, Chen LA, Pei Z, Neto AG, Abidi WM, Ullman T, Mayer L, Bonneau RA, Cho I, Loke P

Validation of a Nurse-Based Delirium-Screening Tool for Hospitalized Patients.


Hargrave A, Bastiaens J, Bourgeois JA, Neuhaus J, Josephson SA, Chinn J, Lee M, Leung J, Douglas V

Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivo.

Wellcome open research

Gras S, Jackson A, Woods S, Pall G, Whitelaw J, Leung JM, Ward GE, Roberts CW, Meissner M

Stability and function of a putative microtubule-organizing center in the human parasite Toxoplasma gondii.

Molecular biology of the cell

Leung JM, He Y, Zhang F, Hwang YC, Nagayasu E, Liu J, Murray JM, Hu K

Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion.

BMC biology

Whitelaw JA, Latorre-Barragan F, Gras S, Pall GS, Leung JM, Heaslip A, Egarter S, Andenmatten N, Nelson SR, Warshaw DM, Ward GE, Meissner M

Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery.

Journal of neuroinflammation

Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM

Reply: heterogeneous population.

British journal of anaesthesia

Hirsch J, Leung JM

Preoperative Sleep Disruption and Postoperative Delirium.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Leung JM, Sands LP, Newman S, Meckler G, Xie Y, Gay C, Lee K

Prognostic Significance of Postoperative Subsyndromal Delirium.


Shim J, DePalma G, Sands LP, Leung JM

Sensitivity and specificity of the animal fluency test for predicting postoperative delirium.

Canadian journal of anaesthesia = Journal canadien d'anesthe´sie

Long LS, Wolpaw JT, Leung JM

The temporal relationship between early postoperative delirium and postoperative cognitive dysfunction in older patients: a prospective cohort study.

Canadian journal of anaesthesia = Journal canadien d'anesthe´sie

Youngblom E, DePalma G, Sands L, Leung J

Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium?

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Leung JM, Sands LP, Lim E, Tsai TL, Kinjo S

Association between intraoperative blood transfusions and early postoperative delirium in older adults.

Journal of the American Geriatrics Society

Behrends M, DePalma G, Sands L, Leung J

Impact of missing data on analysis of postoperative cognitive decline (POCD).

Applied nursing research : ANR

DeCrane SK, Sands LP, Young KM, DePalma G, Leung JM

An update on delirium in the postoperative setting: prevention, diagnosis and management.

Best practice & research. Clinical anaesthesiology

Shim JJ, Leung JM

A brief review of practical preoperative cognitive screening tools.

Canadian journal of anaesthesia = Journal canadien d'anesthe´sie

Long LS, Shapiro WA, Leung JM

Does using a femoral nerve block for total knee replacement decrease postoperative delirium?

BMC anesthesiology

Kinjo S, Lim E, Sands LP, Bozic KJ, Leung JM

Prediction of postoperative pain using path analysis in older patients.

Journal of anesthesia

Kinjo S, Sands LP, Lim E, Paul S, Leung JM

Perioperative cognitive decline in the aging population.

Mayo Clinic proceedings

Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M

Factors associated with recovery from early postoperative delirium.

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses / American Society of PeriAnesthesia Nurses

DeCrane SK, Sands L, Ashland M, Lim E, Tsai TL, Paul S, Leung JM

Postoperative delirium: are there modifiable risk factors?

European journal of anaesthesiology

Leung JM

An Update on Postoperative Cognitive Dysfunction.

Advances in anesthesia

Tsai TL, Sands LP, Leung JM

Does postoperative delirium limit the use of patient-controlled analgesia in older surgical patients?


Leung JM, Sands LP, Paul S, Joseph T, Kinjo S, Tsai T

The effects of postoperative pain and its management on postoperative cognitive dysfunction.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Wang Y, Sands LP, Vaurio L, Mullen EA, Leung JM

Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.


Leung JM, Sands LP, Rico M, Petersen KL, Rowbotham MC, Dahl JB, Ames C, Chou D, Weinstein P

Postoperative delirium: the importance of pain and pain management.

Anesthesia and analgesia

Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung JM

Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients?

The journals of gerontology. Series A, Biological sciences and medical sciences

Leung JM, Sands LP, Mullen EA, Wang Y, Vaurio L

Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery.

Anesthesia and analgesia

Chandy J, Nakai T, Lee RJ, Bellows WH, Dzankic S, Leung JM

The prevalence of preoperative diastolic filling abnormalities in geriatric surgical patients.

Anesthesia and analgesia

Phillip B, Pastor D, Bellows W, Leung JM

Sample size calculations in clinical research.


Bacchetti P, Leung JM

Comparison of left atrial dimensions by transesophageal and transthoracic echocardiography.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Block M, Hourigan L, Bellows WH, Reeves J, Romson JL, Tran M, Pastor D, Schiller NB, Leung JM

The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery.

American heart journal

Nakai T, Lee RJ, Schiller NB, Bellows WH, Dzankic S, Reeves J, Romson J, Ferguson S, Leung JM

Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans.


Leung JM, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P

Predicting adverse postoperative outcomes in patients aged 80 years or older.

Journal of the American Geriatrics Society

Liu LL, Leung JM

Effects of dobutamine on hemodynamics and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients.


Romson JL, Leung JM, Bellows WH, Bronstein M, Keith F, Moores W, Flachsbart K, Richter R, Pastor D, Fisher DM

Automated electrocardiograph ST segment trending monitors: accuracy in detecting myocardial ischemia.

Anesthesia and analgesia

Leung JM, Voskanian A, Bellows WH, Pastor D

Dissociation between haemodynamics and sympathetic activation during anaesthetic induction with desfluranes.

Canadian journal of anaesthesia = Journal canadien d'anesthe´sie

Leung JM, Pastor DA

Human cardiovascular and metabolic response to acute, severe isovolemic anemia.


Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA

Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization.

The Journal of thoracic and cardiovascular surgery

Hennein HA, Ebba H, Rodriguez JL, Merrick SH, Keith FM, Bronstein MH, Leung JM, Mangano DT, Greenfield LJ, Rankin JS

An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. SPI Research Group.

Anesthesia and analgesia

Leung JM, Stanley T, Mathew J, Curling P, Barash P, Salmenpera M, Reves JG, Hollenberg M, Mangano DT

Perioperative monitoring of myocardial ischemia.

International anesthesiology clinics

Bergquist BD, Leung JM

The risk of myocardial ischemia in patients receiving desflurane versus sufentanil anesthesia for coronary artery bypass graft surgery. The S.P.I. Research Group.


Helman JD, Leung JM, Bellows WH, Pineda N, Roach GW, Reeves JD, Howse J, McEnany MT, Mangano DT

Postoperative myocardial ischemia. Therapeutic trials using intensive analgesia following surgery. The Study of Perioperative Ischemia (SPI) Research Group.


Mangano DT, Siliciano D, Hollenberg M, Leung JM, Browner WS, Goehner P, Merrick S, Verrier E

Transesophageal echocardiographic assessment of left ventricular function.

International journal of cardiac imaging

Leung JM, Schiller NB, Mangano DT