Rachel Loewy, PhD

Adjunct Professor
+1 415 476-7659

My research focuses on early identification and intervention in schizophrenia. This includes identifying risk factors for developing psychosis, screening for and diagnosing prodromal psychosis, and testing novel interventions for early psychosis. Most of my current work is focused on implementation of evidence-based practices for early intervention in psychosis in community settings.


Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis.

Translational psychiatry

Baldwin H, Radua J, Antoniades M, Haas SS, Frangou S, Agartz I, Allen P, Andreassen OA, Atkinson K, Bachman P, Baeza I, Bartholomeusz CF, Chee MWL, Colibazzi T, Cooper RE, Corcoran CM, Cropley VL, Ebdrup BH, Fortea A, Glenthøj LB, Hamilton HK, Haut KM, Hayes RA, He Y, Heekeren K, Kaess M, Kasai K, Katagiri N, Kim M, Kindler J, Klaunig MJ, Koike S, Koppel A, Kristensen TD, Bin Kwak Y, Kwon JS, Lawrie SM, Lebedeva I, Lee J, Lin A, Loewy RL, Mathalon DH, Michel C, Mizrahi R, Møller P, Nelson B, Nemoto T, Nordholm D, Omelchenko MA, Pantelis C, Raghava JM, Røssberg JI, Rössler W, Salisbury DF, Sasabayashi D, Schall U, Smigielski L, Sugranyes G, Suzuki M, Takahashi T, Tamnes CK, Tang J, Theodoridou A, Thomopoulos SI, Tomyshev AS, Uhlhaas PJ, Værnes TG, van Amelsvoort TAMJ, Van Erp TGM, Waltz JA, Westlye LT, Wood SJ, Zhou JH, McGuire P, Thompson PM, Jalbrzikowski M, Hernaus D, Fusar-Poli P, ENIGMA Clinical High Risk for Psychosis Working Group

Validation of ketamine as a pharmacological model of thalamic dysconnectivity across the illness course of schizophrenia.

Molecular psychiatry

Abram SV, Roach BJ, Fryer SL, Calhoun VD, Preda A, van Erp TGM, Bustillo JR, Lim KO, Loewy RL, Stuart BK, Krystal JH, Ford JM, Mathalon DH

Online Psychosis Screening: Characterizing an Underexamined Population to Improve Access and Equity.

Psychiatric services (Washington, D.C.)

Savill M, Nguyen T, Shim RS, Loewy RL

Baseline data of a sequential multiple assignment randomized trial (STEP study).

Early intervention in psychiatry

Hartmann JA, Nelson B, Amminger GP, Spark J, Yuen HP, Kerr MJ, Polari A, Wallis N, Blasioli J, Dixon L, Carter C, Loewy R, Niendam TA, Shumway M, McGorry PD

Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.

Schizophrenia bulletin

Loewy R, Fisher M, Ma S, Carter C, Ragland JD, Niendam TA, Stuart B, Schlosser D, Amirfathi F, Yohannes S, Vinogradov S

Persistent and distressing psychotic-like experiences using adolescent brain cognitive development℠ study data.

Molecular psychiatry

Karcher NR, Loewy RL, Savill M, Avenevoli S, Huber RS, Makowski C, Sher KJ, Barch DM

Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis.

JAMA psychiatry

ENIGMA Clinical High Risk for Psychosis Working Group , Jalbrzikowski M, Hayes RA, Wood SJ, Nordholm D, Zhou JH, Fusar-Poli P, Uhlhaas PJ, Takahashi T, Sugranyes G, Kwak YB, Mathalon DH, Katagiri N, Hooker CI, Smigielski L, Colibazzi T, Via E, Tang J, Koike S, Rasser PE, Michel C, Lebedeva I, Hegelstad WTV, de la Fuente-Sandoval C, Waltz JA, Mizrahi R, Corcoran CM, Resch F, Tamnes CK, Haas SS, Lemmers-Jansen ILJ, Agartz I, Allen P, Amminger GP, Andreassen OA, Atkinson K, Bachman P, Baeza I, Baldwin H, Bartholomeusz CF, Borgwardt S, Catalano S, Chee MWL, Chen X, Cho KIK, Cooper RE, Cropley VL, Dolz M, Ebdrup BH, Fortea A, Glenthøj LB, Glenthøj BY, de Haan L, Hamilton HK, Harris MA, Haut KM, He Y, Heekeren K, Heinz A, Hubl D, Hwang WJ, Kaess M, Kasai K, Kim M, Kindler J, Klaunig MJ, Koppel A, Kristensen TD, Kwon JS, Lawrie SM, Lee J, León-Ortiz P, Lin A, Loewy RL, Ma X, McGorry P, McGuire P, Mizuno M, Møller P, Moncada-Habib T, Muñoz-Samons D, Nelson B, Nemoto T, Nordentoft M, Omelchenko MA, Oppedal K, Ouyang L, Pantelis C, Pariente JC, Raghava JM, Reyes-Madrigal F, Roach BJ, Røssberg JI, Rössler W, Salisbury DF, Sasabayashi D, Schall U, Schiffman J, Schlagenhauf F, Schmidt A, Sørensen ME, Suzuki M, Theodoridou A, Tomyshev AS, Tor J, Værnes TG, Velakoulis D, Venegoni GD, Vinogradov S, Wenneberg C, Westlye LT, Yamasue H, Yuan L, Yung AR, van Amelsvoort TAMJ, Turner JA, van Erp TGM, Thompson PM, Hernaus D

Thalamic dysconnectivity in the psychosis risk syndrome and early illness schizophrenia.

Psychological medicine

Fryer SL, Ferri JM, Roach BJ, Loewy RL, Stuart BK, Anticevic A, Ford JM, Mathalon DH

Recommendations to Improve Medication-Assisted Treatment Implementation in Correctional Health.

Psychiatric services (Washington, D.C.)

Barnes CA, Ponce AN, Loewy R

Links Between Human and Animal Models of Trauma and Psychosis: A Narrative Review.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Tryon VL, Garman HD, Loewy RL, Niendam TA

Specificity and Durability of Changes in Auditory Processing Efficiency After Targeted Cognitive Training in Individuals With Recent-Onset Psychosis.

Frontiers in psychiatry

Biagianti B, Fisher M, Loewy R, Brandrett B, Ordorica C, LaCross K, Schermitzler B, McDonald M, Ramsay I, Vinogradov S

Training early psychosis community clinicians in CBT for psychosis: Implementation and feasibility.

Early intervention in psychiatry

Hardy KV, Espil FM, Smith CL, Furuzawa A, Lean M, Zhao Z, Godzikovskaya J, Gilbert A, Loewy RL

Replication of Associations With Psychotic-Like Experiences in Middle Childhood From the Adolescent Brain Cognitive Development (ABCD) Study.

Schizophrenia bulletin open

Karcher NR, Loewy RL, Savill M, Avenevoli S, Huber RS, Simon TJ, Leckliter IN, Sher KJ, Barch DM

Early- Versus Adult-Onset Schizophrenia as a Predictor of Response to Neuroscience-Informed Cognitive Training.

The Journal of clinical psychiatry

Puig O, Fisher M, Loewy R, Miley K, Ramsay IS, Carter CS, Ragland JD, Niendam T, Vinogradov S

Increased global cognition correlates with increased thalamo-temporal connectivity in response to targeted cognitive training for recent onset schizophrenia.

Schizophrenia research

Ramsay IS, Roach BJ, Fryer S, Fisher M, Loewy R, Ford JM, Vinogradov S, Mathalon DH

Psychosis screening in schools: Considerations and implementation strategies.

Early intervention in psychiatry

Meyer MS, Rosenthal A, Bolden KA, Loewy RL, Savill M, Shim R, Rodriguez J, Flores V, Pavao E, Niendam TA

How Do Early Psychosis Services Define and Operationalize the Duration of Untreated Psychosis?

The journal of behavioral health services & research

Savill M, Gosdin M, Patel P, Melnikow J, Loewy R, Niendam T

Recommendations and Challenges of the Clinical Services Panel of the PhenX Early Psychosis Working Group.

Psychiatric services (Washington, D.C.)

Dixon L, Jones N, Loewy R, Perkins D, Sale T, Huggins W, Hamilton C

The Rise of Early Psychosis Care in California: An Overview of Community and University-Based Services.

Psychiatric services (Washington, D.C.)

Niendam TA, Sardo A, Savill M, Patel P, Xing G, Loewy RL, Dewa CS, Melnikow J

Development and testing of a web-based battery to remotely assess cognitive health in individuals with schizophrenia.

Schizophrenia research

Biagianti B, Fisher M, Brandrett B, Schlosser D, Loewy R, Nahum M, Vinogradov S

Efference copy/corollary discharge function and targeted cognitive training in patients with schizophrenia.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology

Roach BJ, Ford JM, Biagianti B, Hamilton HK, Ramsay IS, Fisher M, Loewy R, Vinogradov S, Mathalon DH

Digital Trajectories to Care in First-Episode Psychosis.

Psychiatric services (Washington, D.C.)

Birnbaum ML, Rizvi AF, Faber K, Addington J, Correll CU, Gerber C, Lahti AC, Loewy RL, Mathalon DH, Nelson LA, Voineskos AN, Walker EF, Ward E, Kane JM

Deficient auditory predictive coding during vocalization in the psychosis risk syndrome and in early illness schizophrenia: the final expanded sample.

Psychological medicine

Mathalon DH, Roach BJ, Ferri JM, Loewy RL, Stuart BK, Perez VB, Trujillo TH, Ford JM

Assessment of the Prodromal Questionnaire-Brief Child Version for Measurement of Self-reported Psychoticlike Experiences in Childhood.

JAMA psychiatry

Karcher NR, Barch DM, Avenevoli S, Savill M, Huber RS, Simon TJ, Leckliter IN, Sher KJ, Loewy RL

Transient patterns of functional dysconnectivity in clinical high risk and early-illness schizophrenia individuals compared to healthy controls.

Brain connectivity

Mennigen E, Fryer SL, Rashid B, Damaraju E, Du Y, Loewy RL, Stuart BK, Calhoun VD, Mathalon DH

Reduced higher-dimensional resting state fMRI dynamism in clinical high-risk individuals for schizophrenia identified by meta-state analysis.

Schizophrenia research

Mennigen E, Miller RL, Rashid B, Fryer SL, Loewy RL, Stuart BK, Mathalon DH, Calhoun VD

Which components of specialized early intervention for psychosis do senior providers see as most important?

Early intervention in psychiatry

Savill M, Sardo A, Patel P, Loewy R, Melnikow J, Niendam T

Childhood trauma and clinical high risk for psychosis.

Schizophrenia research

Loewy RL, Corey S, Amirfathi F, Dabit S, Fulford D, Pearson R, Hua JPY, Schlosser D, Stuart BK, Mathalon DH, Vinogradov S

Acceptability of Psychosis Screening and Factors Affecting Its Implementation: Interviews With Community Health Care Providers.

Psychiatric services (Washington, D.C.)

Savill M, Skymba HV, Ragland JD, Niendam T, Loewy RL, Lesh TA, Carter C, Goldman HH

Experience of associative stigma in parents of adolescents at risk for psychosis.

Early intervention in psychiatry

Baron J, Salvador M, Loewy R

Model selection and prediction of outcomes in recent onset schizophrenia patients who undergo cognitive training.

Schizophrenia research. Cognition

Ramsay IS, Ma S, Fisher M, Loewy RL, Ragland JD, Niendam T, Carter CS, Vinogradov S

Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study.

NeuroImage. Clinical

Du Y, Fryer SL, Lin D, Sui J, Yu Q, Chen J, Stuart B, Loewy RL, Calhoun VD, Mathalon DH

Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis.


Du Y, Fryer SL, Fu Z, Lin D, Sui J, Chen J, Damaraju E, Mennigen E, Stuart B, Loewy RL, Mathalon DH, Calhoun VD

Response to Targeted Cognitive Training Correlates with Change in Thalamic Volume in a Randomized Trial for Early Schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Ramsay IS, Fryer S, Boos A, Roach BJ, Fisher M, Loewy R, Vinogradov S, Mathalon DH

Psychosis risk screening in different populations using the Prodromal Questionnaire: A systematic review.

Early intervention in psychiatry

Savill M, D'Ambrosio J, Cannon TD, Loewy RL

Staged Treatment in Early Psychosis: A sequential multiple assignment randomised trial of interventions for ultra high risk of psychosis patients.

Early intervention in psychiatry

Nelson B, Amminger GP, Yuen HP, Wallis N, J Kerr M, Dixon L, Carter C, Loewy R, Niendam TA, Shumway M, Morris S, Blasioli J, McGorry PD

Trait aspects of auditory mismatch negativity predict response to auditory training in individuals with early illness schizophrenia.

Neuropsychiatric electrophysiology

Biagianti B, Roach BJ, Fisher M, Loewy R, Ford JM, Vinogradov S, Mathalon DH

The Role of Trauma and Stressful Life Events among Individuals at Clinical High Risk for Psychosis: A Review.

Frontiers in psychiatry

Mayo D, Corey S, Kelly LH, Yohannes S, Youngquist AL, Stuart BK, Niendam TA, Loewy RL

Metacognitive beliefs mediate the effect of emotional abuse on depressive and psychotic symptoms in severe mental disorders.

Psychological medicine

Østefjells T, Lystad JU, Berg AO, Hagen R, Loewy R, Sandvik L, Melle I, Røssberg JI

The Italian version of the 92-item Prodromal Questionnaire: Concurrent validity with the SIPS and factor analysis in a sample of 258 outpatients aged 11-36years.

Schizophrenia research

Kotzalidis GD, Solfanelli A, Piacentino D, Savoja V, Fiori Nastro P, Curto M, Lindau JF, Masillo A, Brandizzi M, Fagioli F, Raballo A, Gebhardt E, Preti A, D'Alema M, Fucci MR, Miletto R, Andropoli D, Leccisi D, Girardi P, Loewy RL, Schultze-Lutter F

Reduced Amplitude of Low-Frequency Brain Oscillations in the Psychosis Risk Syndrome and Early Illness Schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Fryer SL, Roach BJ, Wiley K, Loewy RL, Ford JM, Mathalon DH

Intensive Auditory Cognitive Training Improves Verbal Memory in Adolescents and Young Adults at Clinical High Risk for Psychosis.

Schizophrenia bulletin

Loewy R, Fisher M, Schlosser DA, Biagianti B, Stuart B, Mathalon DH, Vinogradov S

Modeling the role of negative symptoms in determining social functioning in individuals at clinical high risk of psychosis.

Schizophrenia research

Schlosser DA, Campellone TR, Biagianti B, Delucchi KL, Gard DE, Fulford D, Stuart BK, Fisher M, Loewy RL, Vinogradov S

Symptom assessment in early psychosis: the use of well-established rating scales in clinical high-risk and recent-onset populations.

Psychiatry research

Fulford D, Pearson R, Stuart BK, Fisher M, Mathalon DH, Vinogradov S, Loewy RL

Predicting psychosis and psychiatric hospital care among adolescent psychiatric patients with the Prodromal Questionnaire.

Schizophrenia research

Therman S, Lindgren M, Manninen M, Loewy RL, Huttunen MO, Cannon TD, Suvisaari J

Motivational deficits in individuals at-risk for psychosis and across the course of schizophrenia.

Schizophrenia research

Schlosser DA, Fisher M, Gard D, Fulford D, Loewy RL, Vinogradov S

A novel, online social cognitive training program for young adults with schizophrenia: A pilot study.

Schizophrenia research. Cognition

Nahum M, Fisher M, Loewy R, Poelke G, Ventura J, Nuechterlein KH, Hooker CI, Green MF, Merzenich M, Vinogradov S

Neuroplasticity-based auditory training via laptop computer improves cognition in young individuals with recent onset schizophrenia.

Schizophrenia bulletin

Fisher M, Loewy R, Carter C, Lee A, Ragland JD, Niendam T, Schlosser D, Pham L, Miskovich T, Vinogradov S

The distribution of self-reported psychotic-like experiences in non-psychotic help-seeking mental health patients in the general population; a factor mixture analysis.

Social psychiatry and psychiatric epidemiology

Rietdijk J, Fokkema M, Stahl D, Valmaggia L, Ising HK, Dragt S, Klaassen RM, Nieman DH, Loewy R, Cuijpers P, Delespaul P, Linszen DH, van der Gaag M

Symptom dimensions and functional impairment in early psychosis: more to the story than just negative symptoms.

Schizophrenia research

Fulford D, Niendam TA, Floyd EG, Carter CS, Mathalon DH, Vinogradov S, Stuart BK, Loewy RL

Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia.

Annual review of clinical psychology

Fisher M, Loewy R, Hardy K, Schlosser D, Vinogradov S

The validity of the 16-item version of the Prodromal Questionnaire (PQ-16) to screen for ultra high risk of developing psychosis in the general help-seeking population.

Schizophrenia bulletin

Ising HK, Veling W, Loewy RL, Rietveld MW, Rietdijk J, Dragt S, Klaassen RM, Nieman DH, Wunderink L, Linszen DH, van der Gaag M

Environmental Risk and Protective Factors and Their Influence on the Emergence of Psychosis.

Adolescent psychiatry (Hilversum, Netherlands)

Schlosser DA, Pearson R, Perez VB, Loewy RL

Error monitoring dysfunction across the illness course of schizophrenia.

Journal of abnormal psychology

Perez VB, Ford JM, Roach BJ, Woods SW, McGlashan TH, Srihari VH, Loewy RL, Vinogradov S, Mathalon DH

Filling the implementation gap: a community-academic partnership approach to early intervention in psychosis.

Early intervention in psychiatry

Hardy KV, Moore M, Rose D, Bennett R, Jackson-Lane C, Gause M, Jackson A, Loewy R

Auditory cortex responsiveness during talking and listening: early illness schizophrenia and patients at clinical high-risk for psychosis.

Schizophrenia bulletin

Perez VB, Ford JM, Roach BJ, Loewy RL, Stuart BK, Vinogradov S, Mathalon DH

Prodromal psychosis screening in adolescent psychiatry clinics.

Early intervention in psychiatry

Loewy RL, Therman S, Manninen M, Huttunen MO, Cannon TD

Psychosis risk screening with the Prodromal Questionnaire--brief version (PQ-B).

Schizophrenia research

Loewy RL, Pearson R, Vinogradov S, Bearden CE, Cannon TD

Predicting the longitudinal effects of the family environment on prodromal symptoms and functioning in patients at-risk for psychosis.

Schizophrenia research

Schlosser DA, Zinberg JL, Loewy RL, Casey-Cannon S, O'Brien MP, Bearden CE, Vinogradov S, Cannon TD

Self-report of attenuated psychotic experiences in a college population.

Schizophrenia research

Loewy RL, Johnson JK, Cannon TD

Neurocognitive performance and functional disability in the psychosis prodrome.

Schizophrenia research

Niendam TA, Bearden CE, Johnson JK, McKinley M, Loewy R, O'Brien M, Nuechterlein KH, Green MF, Cannon TD

The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV.

Journal of child and adolescent psychopharmacology

Meyer SE, Bearden CE, Lux SR, Gordon JL, Johnson JK, O'Brien MP, Niendam TA, Loewy RL, Ventura J, Cannon TD

Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions.

Schizophrenia bulletin

Cannon TD, van Erp TG, Bearden CE, Loewy R, Thompson P, Toga AW, Huttunen MO, Keshavan MS, Seidman LJ, Tsuang MT

The management of elder mistreatment: the physician's role.

Wiener klinische Wochenschrift

Hirsch CH, Loewy R

The primary care of elder mistreatment.

The Western journal of medicine

Hirsch CH, Stratton S, Loewy R

Motor dysfunction and risk for schizophrenia.

Development and psychopathology

Walker E, Lewis N, Loewy R, Palyo S